肌注马波沙星在猪组织中残留消除规律

doi:10.11843/j.issn.0366-6964.2014.05.022

Abstract

Abstract:

This experiment was conducted to study tissue residues of marbofloxacin in pigs，preparing for determination of the withdrawal time.Marbofloxacin was administered to 30 healthy pigs intramuscularly at a dosage of 2 mg·kg^－1 for 3 consecutive days.Animals were sacrificed at 0.5，1，3，5，8 d after administration randomly.The tissues were extracted with chloroform，dried under nitrogen at 45 ℃ and cleaned up with hexane.The analytes was detected by UV absorptive spectroscopy after separation by C₁₈ column.The results showed that kidney had the highest drug concentration with 4.93 μg·g^－1at 12 h，the concentration of marbofloxacin in all of tissues at 5 d was lower than the Maximum Residue Limit (MRL).The pharmacokinetic parameters were estimated using Winnonlin software package.The results indicated that the elimination rate was muscle>injection site>kidney>liver>skin/fat，with the elimination half-life of 17.86，17.92，18.20，18.90，21.20 h，respectively.Compared with other tissues，the area under concentration-time curve (AUC) in kidney was highest with 200.16 μg·h·g^－1.Kidney was considered as the target organ.According to the MRL set by EMEA，the longest withdrawal time was suggested in kidney with 5.46 d.The results demonstrated that absorption of marbofloxacin in Pigs after Intramuscular Administration was quickly，distribution was wide and elimination was slowly.It is proposed that the withdrawal time was 6 days.

CLC Number:

S859.84

LI Shuai-peng， HUANG Xian-hui， KONG Xiang-kai， HUAI Bin-bin， WANG Wei， WANG Hui. Residue Elimination of Marbofloxacin in Pigs after Intramuscular Administration[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2014, 45(5): 827-832.

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Residue Elimination of Marbofloxacin in Pigs after Intramuscular Administration

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